Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease
Identifieur interne : 000B86 ( Main/Exploration ); précédent : 000B85; suivant : 000B87Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease
Auteurs : M. Karimi [États-Unis] ; N. Golchin [États-Unis] ; S. D. Tabbal [États-Unis] ; T. Hershey [États-Unis] ; T. O. Videen [États-Unis] ; J. Wu [États-Unis] ; J. W. M. Usche [États-Unis] ; F. J. Revilla [États-Unis] ; J. M. Hartlein [États-Unis] ; A. R. Wernle [États-Unis] ; J. W. Mink [États-Unis] ; J. S. Perlmutter [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2008-10.
Abstract
Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in idiopathic Parkinson's disease, yet the mechanism of action remains unclear. Previous studies indicate that STN DBS increases regional cerebral blood flow (rCBF) in immediate downstream targets but does not reveal which brain regions may have functional changes associated with improved motor manifestations. We studied 48 patients with STN DBS who withheld medication overnight and underwent PET scans to measure rCBF responses to bilateral STN DBS. PET scans were performed with bilateral DBS OFF and ON in a counterbalanced order followed by clinical ratings of motor manifestations using Unified Parkinson Disease Rating Scale 3 (UPDRS 3). We investigated whether improvement in UPDRS 3 scores in rigidity, bradykinesia, postural stability and gait correlate with rCBF responses in a priori determined regions. These regions were selected based on a previous study showing significant STN DBS-induced rCBF change in the thalamus, midbrain and supplementary motor area (SMA). We also chose the pedunculopontine nucleus region (PPN) due to mounting evidence of its involvement in locomotion. In the current study, bilateral STN DBS improved rigidity (62%), bradykinesia (44%), gait (49%) and postural stability (56%) (paired t-tests: P < 0.001). As expected, bilateral STN DBS also increased rCBF in the bilateral thalami, right midbrain, and decreased rCBF in the right premotor cortex (P < 0.05, corrected). There were significant correlations between improvement of rigidity and decreased rCBF in the SMA (rs = –0.4, P < 0.02) and between improvement in bradykinesia and increased rCBF in the thalamus (rs = 0.31, P < 0.05). In addition, improved postural reflexes correlated with decreased rCBF in the PPN (rs = –0.38, P < 0.03). These modest correlations between selective motor manifestations and rCBF in specific regions suggest possible regional selectivity for improvement of different motor signs of Parkinson's disease.
Url:
DOI: 10.1093/brain/awn179
Affiliations:
- États-Unis
- État de New York
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
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Wu</name></author><author><name sortKey="Usche, J W M" sort="Usche, J W M" uniqKey="Usche J" first="J. W. M." last="Usche">J. W. M. Usche</name></author><author><name sortKey="Revilla, F J" sort="Revilla, F J" uniqKey="Revilla F" first="F. J." last="Revilla">F. J. Revilla</name></author><author><name sortKey="Hartlein, J M" sort="Hartlein, J M" uniqKey="Hartlein J" first="J. M." last="Hartlein">J. M. Hartlein</name></author><author><name sortKey="Wernle, A R" sort="Wernle, A R" uniqKey="Wernle A" first="A. R." last="Wernle">A. R. Wernle</name></author><author><name sortKey="Mink, J W" sort="Mink, J W" uniqKey="Mink J" first="J. W." last="Mink">J. W. Mink</name></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. 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Golchin</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Tabbal, S D" sort="Tabbal, S D" uniqKey="Tabbal S" first="S. D." last="Tabbal">S. D. Tabbal</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hershey, T" sort="Hershey, T" uniqKey="Hershey T" first="T." last="Hershey">T. Hershey</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Videen, T O" sort="Videen, T O" uniqKey="Videen T" first="T. O." last="Videen">T. O. 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Revilla</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Hartlein, J M" sort="Hartlein, J M" uniqKey="Hartlein J" first="J. M." last="Hartlein">J. M. Hartlein</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Wernle, A R" sort="Wernle, A R" uniqKey="Wernle A" first="A. R." last="Wernle">A. R. Wernle</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Mink, J W" sort="Mink, J W" uniqKey="Mink J" first="J. W." last="Mink">J. W. Mink</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Department of Psychiatry, Department of Radiology, Department of Anatomy and Neurobiology, Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA, Department of Neurology, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA, Department of Neurology, Department of Neurobiology & Anatomy, Department of Brain & Cognitive Sciences and Department of Pediatrics, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">131</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="2710">2710</biblScope><biblScope unit="page" to="2719">2719</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">FC917030639888E7082D2BDE49535BA50DC49DC2</idno><idno type="DOI">10.1093/brain/awn179</idno><idno type="ArticleID">awn179</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in idiopathic Parkinson's disease, yet the mechanism of action remains unclear. Previous studies indicate that STN DBS increases regional cerebral blood flow (rCBF) in immediate downstream targets but does not reveal which brain regions may have functional changes associated with improved motor manifestations. We studied 48 patients with STN DBS who withheld medication overnight and underwent PET scans to measure rCBF responses to bilateral STN DBS. PET scans were performed with bilateral DBS OFF and ON in a counterbalanced order followed by clinical ratings of motor manifestations using Unified Parkinson Disease Rating Scale 3 (UPDRS 3). We investigated whether improvement in UPDRS 3 scores in rigidity, bradykinesia, postural stability and gait correlate with rCBF responses in a priori determined regions. These regions were selected based on a previous study showing significant STN DBS-induced rCBF change in the thalamus, midbrain and supplementary motor area (SMA). We also chose the pedunculopontine nucleus region (PPN) due to mounting evidence of its involvement in locomotion. In the current study, bilateral STN DBS improved rigidity (62%), bradykinesia (44%), gait (49%) and postural stability (56%) (paired t-tests: P < 0.001). As expected, bilateral STN DBS also increased rCBF in the bilateral thalami, right midbrain, and decreased rCBF in the right premotor cortex (P < 0.05, corrected). There were significant correlations between improvement of rigidity and decreased rCBF in the SMA (rs = –0.4, P < 0.02) and between improvement in bradykinesia and increased rCBF in the thalamus (rs = 0.31, P < 0.05). In addition, improved postural reflexes correlated with decreased rCBF in the PPN (rs = –0.38, P < 0.03). These modest correlations between selective motor manifestations and rCBF in specific regions suggest possible regional selectivity for improvement of different motor signs of Parkinson's disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Karimi, M" sort="Karimi, M" uniqKey="Karimi M" first="M." last="Karimi">M. Karimi</name></region><name sortKey="Golchin, N" sort="Golchin, N" uniqKey="Golchin N" first="N." last="Golchin">N. Golchin</name><name sortKey="Hartlein, J M" sort="Hartlein, J M" uniqKey="Hartlein J" first="J. M." last="Hartlein">J. M. Hartlein</name><name sortKey="Hershey, T" sort="Hershey, T" uniqKey="Hershey T" first="T." last="Hershey">T. Hershey</name><name sortKey="Mink, J W" sort="Mink, J W" uniqKey="Mink J" first="J. W." last="Mink">J. W. Mink</name><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><name sortKey="Revilla, F J" sort="Revilla, F J" uniqKey="Revilla F" first="F. J." last="Revilla">F. J. Revilla</name><name sortKey="Tabbal, S D" sort="Tabbal, S D" uniqKey="Tabbal S" first="S. D." last="Tabbal">S. D. Tabbal</name><name sortKey="Usche, J W M" sort="Usche, J W M" uniqKey="Usche J" first="J. W. M." last="Usche">J. W. M. Usche</name><name sortKey="Videen, T O" sort="Videen, T O" uniqKey="Videen T" first="T. O." last="Videen">T. O. Videen</name><name sortKey="Wernle, A R" sort="Wernle, A R" uniqKey="Wernle A" first="A. R." last="Wernle">A. R. Wernle</name><name sortKey="Wu, J" sort="Wu, J" uniqKey="Wu J" first="J." last="Wu">J. Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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